Differential pharmacological and sex-specific effects of antimuscarinic agents at the hypoglossal motor nucleus in vivo in rats

Successful cholinergic-noradrenergic pharmacotherapy for obstructive sleep apnea (OSA) is thought to be due to effects at the hypoglossal motor nucleus (HMN). Clinical efficacy varies with muscarinic-receptor (MR) subtype affinities. We hypothesized that oxybutynin (cholinergic agent in successful O...

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Detalles Bibliográficos
Autores principales: Niakani, Sepehr, Liu, Hattie, Liu, Wen-Ying, Horner, Richard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437041/
https://www.ncbi.nlm.nih.gov/pubmed/36050440
http://dx.doi.org/10.1038/s41598-022-19233-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437041/
https://www.ncbi.nlm.nih.gov/pubmed/36050440
http://dx.doi.org/10.1038/s41598-022-19233-1

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