Reversible epigenetic alterations regulate class I HLA loss in prostate cancer

Downregulation of HLA class I (HLA-I) impairs immune recognition and surveillance in prostate cancer and may underlie the ineffectiveness of checkpoint blockade. However, the molecular mechanisms regulating HLA-I loss in prostate cancer have not been fully explored. Here, we conducted a comprehensiv...

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Detalles Bibliográficos
Autores principales: Rodems, Tamara S., Heninger, Erika, Stahlfeld, Charlotte N., Gilsdorf, Cole S., Carlson, Kristin N., Kircher, Madison R., Singh, Anupama, Krueger, Timothy E. G., Beebe, David J., Jarrard, David F., McNeel, Douglas G., Haffner, Michael C., Lang, Joshua M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437063/
https://www.ncbi.nlm.nih.gov/pubmed/36050516
http://dx.doi.org/10.1038/s42003-022-03843-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437063/
https://www.ncbi.nlm.nih.gov/pubmed/36050516
http://dx.doi.org/10.1038/s42003-022-03843-6

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