Cargando…

Reversible epigenetic alterations regulate class I HLA loss in prostate cancer

Downregulation of HLA class I (HLA-I) impairs immune recognition and surveillance in prostate cancer and may underlie the ineffectiveness of checkpoint blockade. However, the molecular mechanisms regulating HLA-I loss in prostate cancer have not been fully explored. Here, we conducted a comprehensiv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodems, Tamara S., Heninger, Erika, Stahlfeld, Charlotte N., Gilsdorf, Cole S., Carlson, Kristin N., Kircher, Madison R., Singh, Anupama, Krueger, Timothy E. G., Beebe, David J., Jarrard, David F., McNeel, Douglas G., Haffner, Michael C., Lang, Joshua M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437063/ https://www.ncbi.nlm.nih.gov/pubmed/36050516 http://dx.doi.org/10.1038/s42003-022-03843-6

Ejemplares similares

SEEMLIS: a flexible semi-automated method for enrichment of methylated DNA from low-input samples
por: Rodems, Tamara S., et al.
Publicado: (2022)

Live cell molecular analysis of primary prostate cancer organoids identifies persistent androgen receptor signaling
por: Heninger, Erika, et al.
Publicado: (2021)

Inducible expression of cancer-testis antigens in human prostate cancer
por: Heninger, Erika, et al.
Publicado: (2016)

Inducible expression of antigen processing and antigen presentation molecules and cancer testis antigens in human prostate cancer
por: Heninger, Erika, et al.
Publicado: (2015)

Augmenting Antitumor Immune Responses with Epigenetic Modifying Agents
por: Héninger, Erika, et al.
Publicado: (2015)

Fresh tissue procurement and preparation for multicompartment and multimodal analysis of the prostate tumor microenvironment
por: Vitek, Ross A., et al.
Publicado: (2022)

Development and initial clinical testing of a multiplexed circulating tumor cell assay in patients with clear cell renal cell carcinoma
por: Bade, Rory M., et al.
Publicado: (2021)

Integrated analysis of the tumor microenvironment using a reconfigurable microfluidic cell culture platform
por: Sethakorn, Nan, et al.
Publicado: (2022)

TCR diversity – a universal cancer immunotherapy biomarker?
por: McNeel, Douglas G.
Publicado: (2016)

Toward a More Conclusive Understanding of the Relationship between Musical Training and Reading
por: Jantzen, McNeel G.
Publicado: (2017)

Presence of antigen-specific somatic allelic mutations and splice variants do not predict for immunological response to genetic vaccination
por: Becker, Jordan T, et al.
Publicado: (2013)

Toll-like receptor agonist combinations augment mouse T-cell anti-tumor immunity via IL-12- and interferon ß-mediated suppression of immune checkpoint receptor expression
por: Jeon, Donghwan, et al.
Publicado: (2022)

B cells require licensing by dendritic cells to serve as primary antigen-presenting cells for plasmid DNA
por: Rastogi, Ichwaku, et al.
Publicado: (2023)

Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma
por: Lee, Patrick C., et al.
Publicado: (2022)

The SSX Family of Cancer-Testis Antigens as Target Proteins for Tumor Therapy
por: Smith, Heath A., et al.
Publicado: (2010)

Sipuleucel-T: immunotherapy for advanced prostate cancer
por: Olson, Brian M, et al.
Publicado: (2011)

B lymphocyte mediated antigen presentation of plasmid DNA
por: Colluru, Viswa Teja, et al.
Publicado: (2013)

Monitoring Regulatory Immune Responses in Tumor Immunotherapy Clinical Trials
por: Olson, Brian M., et al.
Publicado: (2013)

SSX expression and function in prostate cancer
por: Bloom, Jordan E, et al.
Publicado: (2013)

SSX2 regulates focal adhesion but does not drive the epithelial to mesenchymal transition in prostate cancer
por: Bloom, Jordan E., et al.
Publicado: (2016)

B lymphocytes as direct antigen-presenting cells for anti-tumor DNA vaccines
por: Colluru, Viswa Teja, et al.
Publicado: (2016)

Vaccines as treatments for prostate cancer
por: Rastogi, Ichwaku, et al.
Publicado: (2023)

Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma
por: Ritter, Cathrin, et al.
Publicado: (2017)

Epitope optimization of a DNA vaccine targeting SSX-2 leads to PD-1 upregulation on antigen-specific CD8 T cells and PD-L1 upregulation on tumor cells
por: Rekoske, Brian, et al.
Publicado: (2013)

Editorial: Overlap of Neural Systems for Processing Language and Music
por: Jantzen, McNeel G., et al.
Publicado: (2016)

HLA antigens in colorectal tumours--low expression of HLA class I antigens in mucinous colorectal carcinomas.
por: van den Ingh, H. F., et al.
Publicado: (1987)

Immunization with a prostate cancer xenoantigen elicits a xenoantigen epitope-specific T-cell response
por: Johnson, Laura E., et al.
Publicado: (2012)

Neurophysiological evidence that musical training influences the recruitment of right hemispheric homologues for speech perception
por: Jantzen, McNeel G., et al.
Publicado: (2014)

Pretreatment antigen-specific immunity and regulation - association with subsequent immune response to anti-tumor DNA vaccination
por: Johnson, Laura E., et al.
Publicado: (2017)

Heterogeneity in past-year smoking, current tobacco use, and smoking cessation behaviors among light and/or non-daily smokers
por: Omole, Toluwa, et al.
Publicado: (2020)

Prevalence of current large cigar versus little cigar/cigarillo smoking among U.S. adults, 2018–2019
por: Phan, Lilianna, et al.
Publicado: (2021)

Advancing Treatment of Bone Metastases through Novel Translational Approaches Targeting the Bone Microenvironment
por: Sethakorn, Nan, et al.
Publicado: (2022)

Targeted Radiation and Immune Therapies—Advances and Opportunities for the Treatment of Prostate Cancer
por: Muralidhar, Anusha, et al.
Publicado: (2023)

Borrelia burgdorferi-Induced Changes in the Class II Self-Immunopeptidome Displayed on HLA-DR Molecules Expressed by Dendritic Cells
por: Gutierrez-Hoffmann, Maria G., et al.
Publicado: (2020)

His-tag ELISA for the detection of humoral tumor-specific immunity
por: Goodell, Vivian, et al.
Publicado: (2008)

ALVR109, an off-the-shelf partially HLA matched SARS-CoV-2–specific T cell therapy, to treat refractory severe COVID-19 pneumonia in a heart transplant patient: Case report
por: Martits-Chalangari, Katalin, et al.
Publicado: (2022)

Combined analysis of HLA class I, HLA-E and HLA-G predicts prognosis in colon cancer patients
por: Zeestraten, E C M, et al.
Publicado: (2014)

Development of a multiplex assay to assess activated p300/CBP in circulating prostate tumor cells
por: Filon, Mikolaj, et al.
Publicado: (2023)

Combined analysis of HLA class I, HLA-E and HLA-G predicts prognosis in colon cancer patients
por: Zeestraten, E C M, et al.
Publicado: (2014)

Infectious Tolerance as Seen With 2020 Vision: The Role of IL-35 and Extracellular Vesicles
por: Sullivan, Jeremy A., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ol82bvlutrj33mjnvcmo4vs56j