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Synthesis and antibacterial activity evaluation of N (7) position-modified balofloxacins
A series of small-molecule fluoroquinolones were synthesized, characterized by HRMS and NMR spectroscopy, and screened for their antibacterial activity against MRSA, P. aeruginosa, and E. coli as model G(+)/G(−) pathogens. Compounds 2-e, 3-e, and 4-e were more potent than the reference drug baloflox...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437215/ https://www.ncbi.nlm.nih.gov/pubmed/36059868 http://dx.doi.org/10.3389/fchem.2022.963442 |