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Synthesis and antibacterial activity evaluation of N (7) position-modified balofloxacins

A series of small-molecule fluoroquinolones were synthesized, characterized by HRMS and NMR spectroscopy, and screened for their antibacterial activity against MRSA, P. aeruginosa, and E. coli as model G(+)/G(−) pathogens. Compounds 2-e, 3-e, and 4-e were more potent than the reference drug baloflox...

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Detalles Bibliográficos
Autores principales:	Hong, Ge, Li, Weitian, Mao, Lina, Wang, Jiawen, Liu, Tianjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437215/ https://www.ncbi.nlm.nih.gov/pubmed/36059868 http://dx.doi.org/10.3389/fchem.2022.963442

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