A combined fragment-based virtual screening and STD-NMR approach for the identification of E-cadherin ligands

Cadherins promote cell-cell adhesion by forming homophilic interactions via their N-terminal extracellular domains. Hence, they have broad-ranging physiological effects on tissue organization and homeostasis. When dysregulated, cadherins contribute to different aspects of cancer progression and meta...

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Detalles Bibliográficos
Autores principales: Vasile, Francesca, Lavore, Francesca, Gazzola, Silvia, Vettraino, Chiara, Parisini, Emilio, Piarulli, Umberto, Belvisi, Laura, Civera, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437437/
https://www.ncbi.nlm.nih.gov/pubmed/36059878
http://dx.doi.org/10.3389/fchem.2022.946087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437437/
https://www.ncbi.nlm.nih.gov/pubmed/36059878
http://dx.doi.org/10.3389/fchem.2022.946087

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