NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron–Sulfur Cluster Proteins

Pancreatic ductal adenocarcinomas (PDAC) depend on autophagy for survival; however, the metabolic substrates that autophagy provides to drive PDAC progression are unclear. Ferritin, the cellular iron storage complex, is targeted for lysosomal degradation (ferritinophagy) by the selective autophagy a...

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Detalles Bibliográficos
Autores principales: Santana-Codina, Naiara, del Rey, Maria Quiles, Kapner, Kevin S., Zhang, Huan, Gikandi, Ajami, Malcolm, Callum, Poupault, Clara, Kuljanin, Miljan, John, Kristen M., Biancur, Douglas E., Chen, Brandon, Das, Nupur K., Lowder, Kristen E., Hennessey, Connor J., Huang, Wesley, Yang, Annan, Shah, Yatrik M., Nowak, Jonathan A., Aguirre, Andrew J., Mancias, Joseph D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437572/
https://www.ncbi.nlm.nih.gov/pubmed/35771492
http://dx.doi.org/10.1158/2159-8290.CD-22-0043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437572/
https://www.ncbi.nlm.nih.gov/pubmed/35771492
http://dx.doi.org/10.1158/2159-8290.CD-22-0043

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