Integrated single-cell transcriptomic analyses reveal that GPNMB-high macrophages promote PN-MES transition and impede T cell activation in GBM

BACKGROUND: Glioblastoma (GBM) is the most aggressive type of primary brain tumor and is often resistant to current therapies. Tumor microenvironment-centered therapies may unleash new hope for GBM treatment. Therefore, an in-depth understanding of tumor-stroma communication is urgently needed to id...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiong, Aizhen, Zhang, Jiwei, Chen, Yan, Zhang, Yi, Yang, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437813/
https://www.ncbi.nlm.nih.gov/pubmed/36054938
http://dx.doi.org/10.1016/j.ebiom.2022.104239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437813/
https://www.ncbi.nlm.nih.gov/pubmed/36054938
http://dx.doi.org/10.1016/j.ebiom.2022.104239

Ejemplares similares