Covalent Organic Framework Based on Azacalix[4]arene for the Efficient Capture of Dialysis Waste Products

[Image: see text] Azacalix[n]arenes (ACAs) are lesser-known cousins of calix[n]arenes that contain amine bridges instead of methylene bridges, so they generally have higher flexibility due to enlarged cavities. Herein, we report a highly substituted cationic azacalix[4]arene-based covalent organic f...

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Autores principales: Skorjanc, Tina, Shetty, Dinesh, Gándara, Felipe, Pascal, Simon, Naleem, Nawavi, Abubakar, Salma, Ali, Liaqat, Mohammed, Abdul Khayum, Raya, Jesus, Kirmizialtin, Serdal, Siri, Olivier, Trabolsi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437870/
https://www.ncbi.nlm.nih.gov/pubmed/35994411
http://dx.doi.org/10.1021/acsami.2c06841
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author Skorjanc, Tina
Shetty, Dinesh
Gándara, Felipe
Pascal, Simon
Naleem, Nawavi
Abubakar, Salma
Ali, Liaqat
Mohammed, Abdul Khayum
Raya, Jesus
Kirmizialtin, Serdal
Siri, Olivier
Trabolsi, Ali
author_facet Skorjanc, Tina
Shetty, Dinesh
Gándara, Felipe
Pascal, Simon
Naleem, Nawavi
Abubakar, Salma
Ali, Liaqat
Mohammed, Abdul Khayum
Raya, Jesus
Kirmizialtin, Serdal
Siri, Olivier
Trabolsi, Ali
author_sort Skorjanc, Tina
collection PubMed
description [Image: see text] Azacalix[n]arenes (ACAs) are lesser-known cousins of calix[n]arenes that contain amine bridges instead of methylene bridges, so they generally have higher flexibility due to enlarged cavities. Herein, we report a highly substituted cationic azacalix[4]arene-based covalent organic framework (ACA-COF) synthesized by the Zincke reaction under microwave irradiation. The current work is a rare example of a synthetic strategy that utilizes the chemical functionalization of an organic macrocycle to constrain its conformational flexibility and, thereby, produce an ordered material. Considering the ACA cavity dimensions, and the density and diversity of the polar groups in ACA-COF, we used it for adsorption of uric acid and creatinine, two major waste products generated during hemodialysis treatment in patients with renal failure. This type of application, which has the potential to save ∼400 L of water per patient per week, has only been recognized in the last decade, but could effectively address the problem of water scarcity in arid areas of the world. Rapid adsorption rates (up to k = 2191 g mg(–1) min(–1)) were observed in our COF, exceeding reported values by several orders of magnitude.
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spelling pubmed-94378702022-09-03 Covalent Organic Framework Based on Azacalix[4]arene for the Efficient Capture of Dialysis Waste Products Skorjanc, Tina Shetty, Dinesh Gándara, Felipe Pascal, Simon Naleem, Nawavi Abubakar, Salma Ali, Liaqat Mohammed, Abdul Khayum Raya, Jesus Kirmizialtin, Serdal Siri, Olivier Trabolsi, Ali ACS Appl Mater Interfaces [Image: see text] Azacalix[n]arenes (ACAs) are lesser-known cousins of calix[n]arenes that contain amine bridges instead of methylene bridges, so they generally have higher flexibility due to enlarged cavities. Herein, we report a highly substituted cationic azacalix[4]arene-based covalent organic framework (ACA-COF) synthesized by the Zincke reaction under microwave irradiation. The current work is a rare example of a synthetic strategy that utilizes the chemical functionalization of an organic macrocycle to constrain its conformational flexibility and, thereby, produce an ordered material. Considering the ACA cavity dimensions, and the density and diversity of the polar groups in ACA-COF, we used it for adsorption of uric acid and creatinine, two major waste products generated during hemodialysis treatment in patients with renal failure. This type of application, which has the potential to save ∼400 L of water per patient per week, has only been recognized in the last decade, but could effectively address the problem of water scarcity in arid areas of the world. Rapid adsorption rates (up to k = 2191 g mg(–1) min(–1)) were observed in our COF, exceeding reported values by several orders of magnitude. American Chemical Society 2022-08-22 2022-08-31 /pmc/articles/PMC9437870/ /pubmed/35994411 http://dx.doi.org/10.1021/acsami.2c06841 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Skorjanc, Tina
Shetty, Dinesh
Gándara, Felipe
Pascal, Simon
Naleem, Nawavi
Abubakar, Salma
Ali, Liaqat
Mohammed, Abdul Khayum
Raya, Jesus
Kirmizialtin, Serdal
Siri, Olivier
Trabolsi, Ali
Covalent Organic Framework Based on Azacalix[4]arene for the Efficient Capture of Dialysis Waste Products
title Covalent Organic Framework Based on Azacalix[4]arene for the Efficient Capture of Dialysis Waste Products
title_full Covalent Organic Framework Based on Azacalix[4]arene for the Efficient Capture of Dialysis Waste Products
title_fullStr Covalent Organic Framework Based on Azacalix[4]arene for the Efficient Capture of Dialysis Waste Products
title_full_unstemmed Covalent Organic Framework Based on Azacalix[4]arene for the Efficient Capture of Dialysis Waste Products
title_short Covalent Organic Framework Based on Azacalix[4]arene for the Efficient Capture of Dialysis Waste Products
title_sort covalent organic framework based on azacalix[4]arene for the efficient capture of dialysis waste products
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437870/
https://www.ncbi.nlm.nih.gov/pubmed/35994411
http://dx.doi.org/10.1021/acsami.2c06841
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