Angiotensin II receptor type 1 blocker candesartan improves morphine tolerance by reducing morphine-induced inflammatory response and cellular activation of BV2 cells via the PPARγ/AMPK signaling pathway

Morphine is the most common drug of choice in clinical pain management; however, morphine tolerance presents a significant clinical challenge. The pathogenesis of morphine tolerance is known to be closely associated with angiotensin II receptor type 1 (AT1R) in microglia. As an AT1R antagonist, cand...

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Detalles Bibliográficos
Autores principales: Zhao, Wenxin, Shen, Feiyan, Yao, Jixiang, Su, Shanshan, Zhao, Zhongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437959/
https://www.ncbi.nlm.nih.gov/pubmed/36004465
http://dx.doi.org/10.3892/mmr.2022.12834

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