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Downregulation of BLM RecQ helicase inhibits proliferation, promotes the apoptosis and enhances the sensitivity of bladder cancer cells to cisplatin

Bloom syndrome protein (BLM) is known to maintain genomic integrity including DNA repair, recombination, replication and transcription. Its dysregulation affects the genomic instability of cells, which results in a high risk of developing various types of cancer and even Bloom syndrome. However, to...

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Detalles Bibliográficos
Autores principales: Feng, Sujuan, Qian, Xiaosong, Feng, Dalin, Zhang, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437972/
https://www.ncbi.nlm.nih.gov/pubmed/36004459
http://dx.doi.org/10.3892/mmr.2022.12829