The m(6)A demethylase ALKBH5-mediated upregulation of DDIT4-AS1 maintains pancreatic cancer stemness and suppresses chemosensitivity by activating the mTOR pathway

BACKGROUND: Chemoresistance is a major factor contributing to the poor prognosis of patients with pancreatic cancer, and cancer stemness is one of the most crucial factors associated with chemoresistance and a very promising direction for cancer treatment. However, the exact molecular mechanisms of...

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Detalles Bibliográficos
Autores principales: Zhang, Yi, Liu, Xiaomeng, Wang, Yan, Lai, Shihui, Wang, Zhiqian, Yang, Yudie, Liu, Wenhui, Wang, Hongquan, Tang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438157/
https://www.ncbi.nlm.nih.gov/pubmed/36056355
http://dx.doi.org/10.1186/s12943-022-01647-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438157/
https://www.ncbi.nlm.nih.gov/pubmed/36056355
http://dx.doi.org/10.1186/s12943-022-01647-0

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