Drp1 activates ROS/HIF-1α/EZH2 and triggers mitochondrial fragmentation to deteriorate hypercalcemia-associated neuronal injury in mouse model of chronic kidney disease

BACKGROUND: Chronic kidney disease (CKD), characterized as renal dysfunction, is regarded as a major public health problem which carries a high risk of cardiovascular diseases. The purpose of this study is to evaluate the functional significance of Drp1 in hypercalcemia-associated neuronal damage fo...

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Detalles Bibliográficos
Autores principales: Sun, Hongming, Li, Xitong, Chen, Xin, Xiong, Yingquan, Cao, Yaochen, Wang, Ziqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438241/
https://www.ncbi.nlm.nih.gov/pubmed/36050772
http://dx.doi.org/10.1186/s12974-022-02542-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438241/
https://www.ncbi.nlm.nih.gov/pubmed/36050772
http://dx.doi.org/10.1186/s12974-022-02542-7

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