Cargando…

Stable expression of a truncated TLX variant drives differentiation of induced pluripotent stem cells into self-renewing neural stem cells for production of extracellular vesicles

BACKGROUND: Neural stem cells (NSCs)-derived extracellular vesicles (EVs) possess great potential in treating severe neurological and cerebrovascular diseases, as they carry the modulatory and regenerative ingredients of NSCs. Induced pluripotent stem cells (iPSCs)-derived NSCs culture represents a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Mingzhi, Chen, Gang, Dong, Yanan, Xiang, Shensi, Xue, Miaomiao, Liu, Yongxue, Song, Haijing, Song, Haifeng, Wang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438273/ https://www.ncbi.nlm.nih.gov/pubmed/36056423 http://dx.doi.org/10.1186/s13287-022-03131-4

Ejemplares similares

Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis
por: Cui, Qi, et al.
Publicado: (2016)

Characterization of TLX Expression in Neural Stem Cells and Progenitor Cells in Adult Brains
por: Li, Shengxiu, et al.
Publicado: (2012)

Feeder cells treated with ethanol can be used to maintain self‐renewal and pluripotency of human pluripotent stem cells
por: Ren, Yahui, et al.
Publicado: (2023)

The TLX1 oncogene drives aneuploidy in T-cell transformation
por: De Keersmaecker, Kim, et al.
Publicado: (2010)

The Function of E-Cadherin in Stem Cell Pluripotency and Self-Renewal
por: Soncin, Francesca, et al.
Publicado: (2011)

WDR36 Safeguards Self-Renewal and Pluripotency of Human Extended Pluripotent Stem Cells
por: An, Shiyu, et al.
Publicado: (2022)

Phosphorylation of ULK1 by AMPK is essential for mouse embryonic stem cell self-renewal and pluripotency
por: Gong, Jiaqi, et al.
Publicado: (2018)

Induced pluripotent stem cells are induced pluripotent stem cell-like cells
por: Song, Liting, et al.
Publicado: (2015)

Mini-TCRs: Truncated T cell receptors to generate T cells from induced pluripotent stem cells
por: Takayanagi, Shin-ichiro, et al.
Publicado: (2023)

Musashi2 Is Required for the Self-Renewal and Pluripotency of Embryonic Stem Cells
por: Wuebben, Erin L., et al.
Publicado: (2012)

Molecular Basis of Mammalian Embryonic Stem Cell Pluripotency and Self-Renewal
por: Medvedev, S.P., et al.
Publicado: (2010)

NPR-A regulates self-renewal and pluripotency of embryonic stem cells
por: Abdelalim, E M, et al.
Publicado: (2011)

Doxycycline Enhances Survival and Self-Renewal of Human Pluripotent Stem Cells
por: Chang, Mi-Yoon, et al.
Publicado: (2014)

A Stem Cell Reporter for Investigating Pluripotency and Self-Renewal in the Rat
por: Meek, Stephen, et al.
Publicado: (2020)

Enhanced self-renewal of human pluripotent stem cells by simulated microgravity
por: Timilsina, S., et al.
Publicado: (2022)

Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells
por: Varzideh, Fahimeh, et al.
Publicado: (2023)

Tailless/TLX reverts intermediate neural progenitors to stem cells driving tumourigenesis via repression of asense/ASCL1
por: Hakes, Anna E, et al.
Publicado: (2020)

Gas5 is an essential lncRNA regulator for self-renewal and pluripotency of mouse embryonic stem cells and induced pluripotent stem cells
por: Tu, Jiajie, et al.
Publicado: (2018)

The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model
por: Murai, Kiyohito, et al.
Publicado: (2016)

Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver
por: Suzuki, Atsushi, et al.
Publicado: (2002)

Protein Kinase C Regulates Human Pluripotent Stem Cell Self-Renewal
por: Kinehara, Masaki, et al.
Publicado: (2013)

Exogenous LIN28 Is Required for the Maintenance of Self-Renewal and Pluripotency in Presumptive Porcine-Induced Pluripotent Stem Cells
por: Chakritbudsabong, Warunya, et al.
Publicado: (2021)

Nucleostemin maintains self-renewal of embryonic stem cells and promotes reprogramming of somatic cells to pluripotency
por: Qu, Jian, et al.
Publicado: (2012)

Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming
por: Islam, Mohammed M., et al.
Publicado: (2015)

Differential Coupling of Self-Renewal Signaling Pathways in Murine Induced Pluripotent Stem Cells
por: Orlando, Luca, et al.
Publicado: (2012)

Self-Renewal and Pluripotency Acquired through Somatic Reprogramming to Human Cancer Stem Cells
por: Nagata, Shogo, et al.
Publicado: (2012)

α-5 Laminin Synthesized by Human Pluripotent Stem Cells Promotes Self-Renewal
por: Laperle, Alex, et al.
Publicado: (2015)

EGFR deficiency leads to impaired self-renewal and pluripotency of mouse embryonic stem cells
por: Yu, Miaoying, et al.
Publicado: (2019)

Dppa3 facilitates self-renewal of embryonic stem cells by stabilization of pluripotent factors
por: Zhao, Shuang, et al.
Publicado: (2022)

MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells
por: Müller, Iris, et al.
Publicado: (2021)

Pluripotency-State-Dependent Role of Dax1 in Embryonic Stem Cells Self-Renewal
por: He, Jianrong, et al.
Publicado: (2021)

Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia
por: Vanden Bempt, Marlies, et al.
Publicado: (2018)

Single-Cell Gene Expression Profiles Define Self-Renewing, Pluripotent, and Lineage Primed States of Human Pluripotent Stem Cells
por: Hough, Shelley R., et al.
Publicado: (2014)

Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo
por: Reinhardt, Robert, et al.
Publicado: (2015)

Self-Renewal of Stem Cells
por: Terskikh, V.V., et al.
Publicado: (2009)

TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival
por: Chavali, P L, et al.
Publicado: (2014)

SVM classifier to predict genes important for self-renewal and pluripotency of mouse embryonic stem cells
por: Xu, Huilei, et al.
Publicado: (2010)

Construction and Validation of a Regulatory Network for Pluripotency and Self-Renewal of Mouse Embryonic Stem Cells
por: Xu, Huilei, et al.
Publicado: (2014)

Mechanistic Analysis of Physicochemical Cues in Promoting Human Pluripotent Stem Cell Self-Renewal and Metabolism
por: Hai, Nan, et al.
Publicado: (2018)

Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal
por: Lau, Kevin X., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hes79oiq3fa8dfbqklf6kmt4l3