Predicting and explaining the impact of genetic disruptions and interactions on organismal viability

MOTIVATION: Existing computational models can predict single- and double-mutant fitness but they do have limitations. First, they are often tested via evaluation metrics that are inappropriate for imbalanced datasets. Second, all of them only predict a binary outcome (viable or not, and negatively i...

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Detalles Bibliográficos
Autores principales: Al-Anzi, Bader F, Khajah, Mohammad, Fakhraldeen, Saja A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438956/
https://www.ncbi.nlm.nih.gov/pubmed/35861390
http://dx.doi.org/10.1093/bioinformatics/btac519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438956/
https://www.ncbi.nlm.nih.gov/pubmed/35861390
http://dx.doi.org/10.1093/bioinformatics/btac519

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