EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS (G12D) tumor development and propagation

Lung development, integrity and repair rely on precise Wnt signaling, which is corrupted in diverse diseases, including cancer. Here, we discover that EHMT2 methyltransferase regulates Wnt signaling in the lung by controlling the transcriptional activity of chromatin-bound β-catenin, through a non-h...

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Detalles Bibliográficos
Autores principales: Pribluda, Ariel, Daemen, Anneleen, Lima, Anthony Nelson, Wang, Xi, Hafner, Marc, Poon, Chungkee, Modrusan, Zora, Katakam, Anand Kumar, Foreman, Oded, Eastham, Jefferey, Hung, Jefferey, Haley, Benjamin, Garcia, Julia T, Jackson, Erica L, Junttila, Melissa R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439681/
https://www.ncbi.nlm.nih.gov/pubmed/35983994
http://dx.doi.org/10.7554/eLife.57648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439681/
https://www.ncbi.nlm.nih.gov/pubmed/35983994
http://dx.doi.org/10.7554/eLife.57648

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