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A paternal bias in germline mutation is widespread in amniotes and can arise independently of cell division numbers

In humans and other mammals, germline mutations are more likely to arise in fathers than in mothers. Although this sex bias has long been attributed to DNA replication errors in spermatogenesis, recent evidence from humans points to the importance of mutagenic processes that do not depend on cell di...

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Detalles Bibliográficos
Autores principales: de Manuel, Marc, Wu, Felix L, Przeworski, Molly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439683/
https://www.ncbi.nlm.nih.gov/pubmed/35916372
http://dx.doi.org/10.7554/eLife.80008