Repository Describing the Anatomical, Physiological, and Biological Changes in an Obese Population to Inform Physiologically Based Pharmacokinetic Models

BACKGROUND: Obesity is associated with physiological changes that can affect drug pharmacokinetics. Obese individuals are underrepresented in clinical trials, leading to a lack of evidence-based dosing recommendations for many drugs. Physiologically based pharmacokinetic (PBPK) modelling can overcom...

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Detalles Bibliográficos
Autores principales: Berton, Mattia, Bettonte, Sara, Stader, Felix, Battegay, Manuel, Marzolini, Catia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439993/
https://www.ncbi.nlm.nih.gov/pubmed/35699913
http://dx.doi.org/10.1007/s40262-022-01132-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439993/
https://www.ncbi.nlm.nih.gov/pubmed/35699913
http://dx.doi.org/10.1007/s40262-022-01132-3

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