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Repository Describing the Anatomical, Physiological, and Biological Changes in an Obese Population to Inform Physiologically Based Pharmacokinetic Models

BACKGROUND: Obesity is associated with physiological changes that can affect drug pharmacokinetics. Obese individuals are underrepresented in clinical trials, leading to a lack of evidence-based dosing recommendations for many drugs. Physiologically based pharmacokinetic (PBPK) modelling can overcom...

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Detalles Bibliográficos
Autores principales:	Berton, Mattia, Bettonte, Sara, Stader, Felix, Battegay, Manuel, Marzolini, Catia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439993/ https://www.ncbi.nlm.nih.gov/pubmed/35699913 http://dx.doi.org/10.1007/s40262-022-01132-3

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