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Mitochondrial Ca(2+) uptake by the MCU facilitates pyramidal neuron excitability and metabolism during action potential firing

Neuronal activation is fundamental to information processing by the brain and requires mitochondrial energy metabolism. Mitochondrial Ca(2+) uptake by the mitochondrial Ca(2+) uniporter (MCU) has long been implicated in the control of energy metabolism and intracellular Ca(2+) signalling, but its im...

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Detalles Bibliográficos
Autores principales: Groten, Christopher J., MacVicar, Brian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440007/
https://www.ncbi.nlm.nih.gov/pubmed/36056095
http://dx.doi.org/10.1038/s42003-022-03848-1