MeCP2 inhibits ischemic neuronal injury by enhancing methylation of the FOXO3a promoter to repress the SPRY2-ZEB1 axis

Methyl CpG binding protein 2 (MeCP2) is involved in nerve regeneration following ischemic stroke, but the related mechanism remains unclear. Here, we found low MeCP2 expression in hippocampal tissues. Using functional analysis, we demonstrated that MeCP2 accelerated FOXO3a methylation and subsequent...

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Detalles Bibliográficos
Autores principales: Meng, Lei, Feng, Bin, Luan, Liming, Fang, Zhihao, Zhao, Guangyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440071/
https://www.ncbi.nlm.nih.gov/pubmed/35915222
http://dx.doi.org/10.1038/s12276-022-00790-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440071/
https://www.ncbi.nlm.nih.gov/pubmed/35915222
http://dx.doi.org/10.1038/s12276-022-00790-4

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