Role of redox-sensitive catalytic interaction with ADAM10 in mutant-selective extracellular shedding of prion protein

Misfolded glycosylphosphatidylinositol-anchored prion protein (PrP) is primarily degraded in lysosomes but is often rapidly removed from the cell surface before endocytosis in a preemptive manner. However, this mechanism is poorly understood. In this study, we discovered a disease-causing prion muta...

Descripción completa

Detalles Bibliográficos
Autores principales: Shin, Yejin, Jo, Kang-Sug, Shin, Minseok, Lee, Duri, Yeo, Hyejin, Song, Youngsup, Kang, Sang-Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440079/
https://www.ncbi.nlm.nih.gov/pubmed/36041363
http://dx.doi.org/10.1016/j.redox.2022.102456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440079/
https://www.ncbi.nlm.nih.gov/pubmed/36041363
http://dx.doi.org/10.1016/j.redox.2022.102456

Ejemplares similares