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Role of redox-sensitive catalytic interaction with ADAM10 in mutant-selective extracellular shedding of prion protein
Misfolded glycosylphosphatidylinositol-anchored prion protein (PrP) is primarily degraded in lysosomes but is often rapidly removed from the cell surface before endocytosis in a preemptive manner. However, this mechanism is poorly understood. In this study, we discovered a disease-causing prion muta...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440079/ https://www.ncbi.nlm.nih.gov/pubmed/36041363 http://dx.doi.org/10.1016/j.redox.2022.102456 |