Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy

Mitophagy is essential to maintain mitochondrial function and prevent diseases. It activates upon mitochondria depolarization, which causes PINK1 stabilization on the mitochondrial outer membrane. Strikingly, a number of conditions, including mitochondrial protein misfolding, can induce mitophagy wi...

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Detalles Bibliográficos
Autores principales: Michaelis, Jonas Benjamin, Brunstein, Melinda Elaine, Bozkurt, Süleyman, Alves, Ludovico, Wegner, Martin, Kaulich, Manuel, Pohl, Christian, Münch, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440083/
https://www.ncbi.nlm.nih.gov/pubmed/36056001
http://dx.doi.org/10.1038/s41467-022-32564-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440083/
https://www.ncbi.nlm.nih.gov/pubmed/36056001
http://dx.doi.org/10.1038/s41467-022-32564-x

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