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Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy
Mitophagy is essential to maintain mitochondrial function and prevent diseases. It activates upon mitochondria depolarization, which causes PINK1 stabilization on the mitochondrial outer membrane. Strikingly, a number of conditions, including mitochondrial protein misfolding, can induce mitophagy wi...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440083/ https://www.ncbi.nlm.nih.gov/pubmed/36056001 http://dx.doi.org/10.1038/s41467-022-32564-x |