3D proximal tubule-on-chip model derived from kidney organoids with improved drug uptake

Three-dimensional, organ-on-chip models that recapitulate kidney tissue are needed for drug screening and disease modeling. Here, we report a method for creating a perfusable 3D proximal tubule model composed of epithelial cells isolated from kidney organoids matured under static conditions. These o...

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Detalles Bibliográficos
Autores principales: Aceves, Jeffrey O., Heja, Szilvia, Kobayashi, Kenichi, Robinson, Sanlin S., Miyoshi, Tomoya, Matsumoto, Takuya, Schäffers, Olivier J. M., Morizane, Ryuji, Lewis, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440090/
https://www.ncbi.nlm.nih.gov/pubmed/36056134
http://dx.doi.org/10.1038/s41598-022-19293-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440090/
https://www.ncbi.nlm.nih.gov/pubmed/36056134
http://dx.doi.org/10.1038/s41598-022-19293-3

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