Akt1-dependent expression of angiopoietin 1 and 2 in vascular smooth muscle cells leads to vascular stabilization

Retinal angiogenesis was delayed in VSMC-specific Akt1-deficient mice (Akt1(∆SMC)) but not in Akt2(∆SMC) mice. The proliferation of ECs, recruitment of pericytes, and coverage of VSMCs to the endothelium were defective in Akt1(∆SMC). The silencing of Akt1 in VSMCs led to the downregulation of angiop...

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Detalles Bibliográficos
Autores principales: Ha, Jung Min, Jin, Seo Yeon, Lee, Hye Sun, Kum, Hye Jin, Vafaeinik, Farzaneh, Ha, Hong Koo, Song, Sang Heon, Kim, Chi Dae, Bae, Sun Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440121/
https://www.ncbi.nlm.nih.gov/pubmed/35931736
http://dx.doi.org/10.1038/s12276-022-00819-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440121/
https://www.ncbi.nlm.nih.gov/pubmed/35931736
http://dx.doi.org/10.1038/s12276-022-00819-8

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