Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation

Oxidation of the epigenetic DNA mark 5-methylcytosine by Tet dioxygenases is an established route to diversify the epigenetic information, modulate gene expression and overall cellular (patho-)physiology. Here, we demonstrate that Tet1 and its short isoform Tet1s exhibit distinct nuclear localizatio...

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Detalles Bibliográficos
Autores principales: Arroyo, María, Hastert, Florian D., Zhadan, Andreas, Schelter, Florian, Zimbelmann, Susanne, Rausch, Cathia, Ludwig, Anne K., Carell, Thomas, Cardoso, M. Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440122/
https://www.ncbi.nlm.nih.gov/pubmed/36056023
http://dx.doi.org/10.1038/s41467-022-32799-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440122/
https://www.ncbi.nlm.nih.gov/pubmed/36056023
http://dx.doi.org/10.1038/s41467-022-32799-8

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