Proton-driven alternating access in a spinster lipid transporter

Spinster (Spns) lipid transporters are critical for transporting sphingosine-1-phosphate (S1P) across cellular membranes. In humans, Spns2 functions as the main S1P transporter in endothelial cells, making it a potential drug target for modulating S1P signaling. Here, we employed an integrated appro...

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Detalles Bibliográficos
Autores principales: Dastvan, Reza, Rasouli, Ali, Dehghani-Ghahnaviyeh, Sepehr, Gies, Samantha, Tajkhorshid, Emad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440201/
https://www.ncbi.nlm.nih.gov/pubmed/36055994
http://dx.doi.org/10.1038/s41467-022-32759-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440201/
https://www.ncbi.nlm.nih.gov/pubmed/36055994
http://dx.doi.org/10.1038/s41467-022-32759-2

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