Automated model-predictive design of synthetic promoters to control transcriptional profiles in bacteria

Transcription rates are regulated by the interactions between RNA polymerase, sigma factor, and promoter DNA sequences in bacteria. However, it remains unclear how non-canonical sequence motifs collectively control transcription rates. Here, we combine massively parallel assays, biophysics, and mach...

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Detalles Bibliográficos
Autores principales: LaFleur, Travis L., Hossain, Ayaan, Salis, Howard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440211/
https://www.ncbi.nlm.nih.gov/pubmed/36056029
http://dx.doi.org/10.1038/s41467-022-32829-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440211/
https://www.ncbi.nlm.nih.gov/pubmed/36056029
http://dx.doi.org/10.1038/s41467-022-32829-5

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