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Automated model-predictive design of synthetic promoters to control transcriptional profiles in bacteria
Transcription rates are regulated by the interactions between RNA polymerase, sigma factor, and promoter DNA sequences in bacteria. However, it remains unclear how non-canonical sequence motifs collectively control transcription rates. Here, we combine massively parallel assays, biophysics, and mach...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440211/ https://www.ncbi.nlm.nih.gov/pubmed/36056029 http://dx.doi.org/10.1038/s41467-022-32829-5 |