Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop

BRCA1 maintains genome stability by promoting homologous recombination (HR)-mediated DNA double-strand break (DSB) repair. Mutation of mouse BRCA1-S1152, corresponding to an ATM phosphorylation site in its human counterpart, resulted in increased genomic instability and tumor incidence. In this stud...

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Detalles Bibliográficos
Autores principales: Qi, Leilei, Chakravarthy, Reka, Li, Monica M., Deng, Chu-Xia, Li, Rong, Hu, Yanfen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440284/
https://www.ncbi.nlm.nih.gov/pubmed/36065181
http://dx.doi.org/10.1016/j.isci.2022.104944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440284/
https://www.ncbi.nlm.nih.gov/pubmed/36065181
http://dx.doi.org/10.1016/j.isci.2022.104944

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