X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the pathogen that causes COVID-19, produces polyproteins 1a and 1ab that contain, respectively, 11 or 16 non-structural proteins (nsp). Nsp5 is the main protease (M(pro)) responsible for cleavage at eleven positions along these polyprotei...

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Detalles Bibliográficos
Autores principales: Lee, Jaeyong, Kenward, Calem, Worrall, Liam J., Vuckovic, Marija, Gentile, Francesco, Ton, Anh-Tien, Ng, Myles, Cherkasov, Artem, Strynadka, Natalie C. J., Paetzel, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440467/
https://www.ncbi.nlm.nih.gov/pubmed/36057636
http://dx.doi.org/10.1038/s41467-022-32854-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440467/
https://www.ncbi.nlm.nih.gov/pubmed/36057636
http://dx.doi.org/10.1038/s41467-022-32854-4

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