Cargando…

X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the pathogen that causes COVID-19, produces polyproteins 1a and 1ab that contain, respectively, 11 or 16 non-structural proteins (nsp). Nsp5 is the main protease (M(pro)) responsible for cleavage at eleven positions along these polyprotei...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Jaeyong, Kenward, Calem, Worrall, Liam J., Vuckovic, Marija, Gentile, Francesco, Ton, Anh-Tien, Ng, Myles, Cherkasov, Artem, Strynadka, Natalie C. J., Paetzel, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440467/ https://www.ncbi.nlm.nih.gov/pubmed/36057636 http://dx.doi.org/10.1038/s41467-022-32854-4

Ejemplares similares

Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site
por: Lee, Jaeyong, et al.
Publicado: (2020)

A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants
por: Pérez-Vargas, Jimena, et al.
Publicado: (2023)

Automated discovery of noncovalent inhibitors of SARS-CoV-2 main protease by consensus Deep Docking of 40 billion small molecules
por: Gentile, Francesco, et al.
Publicado: (2021)

Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2
por: Zhao, Yao, et al.
Publicado: (2022)

Targeting SARS-CoV-2 papain-like protease in the postvaccine era
por: Ton, Anh-Tien, et al.
Publicado: (2022)

Identification of the protease cleavage sites in a reconstituted Gag polyprotein of an HERV-K(HML-2) element
por: George, Maja, et al.
Publicado: (2011)

Insights into the Dynamics and Binding of Two Polyprotein Substrate Cleavage Points in the Context of the SARS-CoV-2 Main and Papain-like Proteases
por: Sanusi, Zainab Kemi, et al.
Publicado: (2022)

Identification of Cleavage Sites Recognized by the 3C-Like Cysteine Protease within the Two Polyproteins of Strawberry Mottle Virus
por: Mann, Krin S., et al.
Publicado: (2017)

Identification of Cleavage Sites Proteolytically Processed by NS2B-NS3 Protease in Polyprotein of Japanese Encephalitis Virus
por: Wahaab, Abdul, et al.
Publicado: (2021)

Corrigendum: Identification of Cleavage Sites Recognized by the 3C-Like Cysteine Protease within the Two Polyproteins of Strawberry Mottle Virus
por: Mann, Krin S., et al.
Publicado: (2017)

Re-examination of nepovirus polyprotein cleavage sites highlights the diverse specificities and evolutionary relationships of nepovirus 3C-like proteases
por: Sanfaçon, Hélène
Publicado: (2022)

X-ray crystallographic structure of a bacterial polysialyltransferase provides insight into the biosynthesis of capsular polysialic acid
por: Lizak, Christian, et al.
Publicado: (2017)

Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry
por: Majewski, Dorothy D., et al.
Publicado: (2019)

Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus
por: Alexander, J. Andrew N., et al.
Publicado: (2023)

Antiviral drug discovery by targeting the SARS-CoV-2 polyprotein processing by inhibition of the main protease
por: Kandeel, Mahmoud, et al.
Publicado: (2022)

A Cell-based Fluorescence Resonance Energy Transfer (FRET) Sensor Reveals Inter- and Intragenogroup Variations in Norovirus Protease Activity and Polyprotein Cleavage
por: Emmott, Edward, et al.
Publicado: (2015)

Analysis of proteolytic processing sites in potyvirus polyproteins revealed differential amino acid preferences of NIa-Pro protease in each of seven cleavage sites
por: Goh, Chul Jun, et al.
Publicado: (2021)

Polyprotein cleavage mechanism of SARS CoV M(pro) and chemical modification of the octapeptide
por: Du, Qi-Shi, et al.
Publicado: (2004)

Preliminary crystallographic analysis of avian infectious bronchitis virus main protease
por: Li, Jun, et al.
Publicado: (2006)

Deep Docking: A Deep Learning Platform for Augmentation of Structure Based Drug Discovery
por: Gentile, Francesco, et al.
Publicado: (2020)

Role of cleavage at the core-E1 junction of hepatitis C virus polyprotein in viral morphogenesis
por: Pène, Véronique, et al.
Publicado: (2017)

SARS-CoV-2 polyprotein substrate regulates the stepwise M(pro) cleavage reaction
por: Narwal, Manju, et al.
Publicado: (2023)

Thrombin cleavage of the hepatitis E virus polyprotein at multiple conserved locations is required for genome replication
por: Pierce, Danielle M., et al.
Publicado: (2023)

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
por: Douangamath, Alice, et al.
Publicado: (2020)

Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli
por: Caveney, Nathanael A., et al.
Publicado: (2019)

Inhibition of 2A-mediated ‘cleavage’ of certain artificial polyproteins bearing N-terminal signal sequences
por: de Felipe, Pablo, et al.
Publicado: (2010)

Polyproteins in structural biology
por: Crépin, Thibaut, et al.
Publicado: (2015)

A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process
por: Noske, G.D., et al.
Publicado: (2021)

Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode
por: Chen, Shuai, et al.
Publicado: (2010)

Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling
por: Workman, Sean D., et al.
Publicado: (2018)

Crystallization and preliminary crystallographic study of human coronavirus NL63 main protease in complex with an inhibitor
por: Wang, Fenghua, et al.
Publicado: (2014)

Crystallization and preliminary crystallographic study of Porcine epidemic diarrhea virus main protease in complex with an inhibitor
por: Tan, Yusheng, et al.
Publicado: (2014)

Crystallization and preliminary crystallographic study of Feline infectious peritonitis virus main protease in complex with an inhibitor
por: Wang, Jinshan, et al.
Publicado: (2014)

Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics
por: Kaul, Artur, et al.
Publicado: (2009)

Characterization of the protease domain of Rice tungro bacilliform virus responsible for the processing of the capsid protein from the polyprotein
por: Marmey, Philippe, et al.
Publicado: (2005)

Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor
por: Schimer, Jiří, et al.
Publicado: (2015)

Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)
por: Harrison, Jerry Joe E. K., et al.
Publicado: (2021)

Erratum to: Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode
por: Chen, Shuai, et al.
Publicado: (2010)

Dual-Inhibitors of N-Myc and AURKA as Potential Therapy for Neuroendocrine Prostate Cancer
por: Ton, Anh-Tien, et al.
Publicado: (2020)

Correction: Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics
por: Kaul, Artur, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_oufkcqcjprkcihg03jv0aqp8ru