Non-synonymous to synonymous substitutions suggest that orthologs tend to keep their functions, while paralogs are a source of functional novelty

Orthologs separate after lineages split from each other and paralogs after gene duplications. Thus, orthologs are expected to remain more functionally coherent across lineages, while paralogs have been proposed as a source of new functions. Because protein functional divergence follows from non-syno...

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Detalles Bibliográficos
Autores principales: Escorcia-Rodríguez, Juan M., Esposito, Mario, Freyre-González, Julio A., Moreno-Hagelsieb, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2022
Materias:
Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440661/
https://www.ncbi.nlm.nih.gov/pubmed/36065404
http://dx.doi.org/10.7717/peerj.13843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440661/
https://www.ncbi.nlm.nih.gov/pubmed/36065404
http://dx.doi.org/10.7717/peerj.13843

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