Heterotropic roles of divalent cations in the establishment of allostery and affinity maturation of integrin αXβ2

Allosteric activation and silencing of leukocyte β2-integrins transpire through cation-dependent structural changes, which mediate integrin biosynthesis and recycling, and are essential to designing leukocyte-specific drugs. Stepwise addition of Mg(2+) reveals two mutually coupled events for the αXβ...

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Detalles Bibliográficos
Autores principales: Manandhar, Pragya, Mazhar, Zahra, Abousaway, Omar, Aboagye, Collins, Moussa, Zeinab, Lim, Daniel, Yu, Tannon, Byrnes, James, Briggs, James M., Sen, Mehmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440770/
https://www.ncbi.nlm.nih.gov/pubmed/36001965
http://dx.doi.org/10.1016/j.celrep.2022.111254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440770/
https://www.ncbi.nlm.nih.gov/pubmed/36001965
http://dx.doi.org/10.1016/j.celrep.2022.111254

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