Inhibiting ERK dimerization ameliorates BRAF-driven anaplastic thyroid cancer

BACKGROUND: RAS-to-ERK signaling is crucial for the onset and progression of advanced thyroid carcinoma, and blocking ERK dimerization provides a therapeutic benefit in several human carcinomas. Here we analyzed the effects of DEL-22379, a relatively specific ERK dimerization inhibitor, on the activ...

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Detalles Bibliográficos
Autores principales: Zaballos, Miguel A., Acuña-Ruiz, Adrián, Morante, Marta, Riesco-Eizaguirre, Garcilaso, Crespo, Piero, Santisteban, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440884/
https://www.ncbi.nlm.nih.gov/pubmed/36056964
http://dx.doi.org/10.1007/s00018-022-04530-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440884/
https://www.ncbi.nlm.nih.gov/pubmed/36056964
http://dx.doi.org/10.1007/s00018-022-04530-9

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