Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression

Spermidine is a natural polyamine that has health benefits and extends life span in several species. Deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH) are key enzymes that utilize spermidine to catalyze the post-translational hypusination of the translation factor EIF5A (EIF5A(H))....

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Detalles Bibliográficos
Autores principales: Zhou, Jin, Pang, Jeremy, Tripathi, Madhulika, Ho, Jia Pei, Widjaja, Anissa Anindya, Shekeran, Shamini Guna, Cook, Stuart Alexander, Suzuki, Ayako, Diehl, Anna Mae, Petretto, Enrico, Singh, Brijesh Kumar, Yen, Paul Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440896/
https://www.ncbi.nlm.nih.gov/pubmed/36057633
http://dx.doi.org/10.1038/s41467-022-32788-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440896/
https://www.ncbi.nlm.nih.gov/pubmed/36057633
http://dx.doi.org/10.1038/s41467-022-32788-x

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