Engineered model of t(7;12)(q36;p13) AML recapitulates patient-specific features and gene expression profiles

Acute myeloid leukaemia carrying the translocation t(7;12)(q36;p13) is an adverse-risk leukaemia uniquely observed in infants. Despite constituting up to 30% of cases in under 2-year-olds, it remains poorly understood. Known molecular features are ectopic overexpression of the MNX1 gene and generati...

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Detalles Bibliográficos
Autores principales: Ragusa, Denise, Cicirò, Ylenia, Federico, Concetta, Saccone, Salvatore, Bruno, Francesca, Saeedi, Reza, Sisu, Cristina, Pina, Cristina, Sala, Arturo, Tosi, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440899/
https://www.ncbi.nlm.nih.gov/pubmed/36057683
http://dx.doi.org/10.1038/s41389-022-00426-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440899/
https://www.ncbi.nlm.nih.gov/pubmed/36057683
http://dx.doi.org/10.1038/s41389-022-00426-2

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