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Engineered model of t(7;12)(q36;p13) AML recapitulates patient-specific features and gene expression profiles
Acute myeloid leukaemia carrying the translocation t(7;12)(q36;p13) is an adverse-risk leukaemia uniquely observed in infants. Despite constituting up to 30% of cases in under 2-year-olds, it remains poorly understood. Known molecular features are ectopic overexpression of the MNX1 gene and generati...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440899/ https://www.ncbi.nlm.nih.gov/pubmed/36057683 http://dx.doi.org/10.1038/s41389-022-00426-2 |