Stereoretentive cross-coupling of chiral amino acid chlorides and hydrocarbons through mechanistically controlled Ni/Ir photoredox catalysis

The direct modification of naturally occurring chiral amino acids to their amino ketone analogs is a significant synthetic challenge. Here, an efficient and robust cross-coupling reaction between chiral amino acid chlorides and unactivated C(sp(3))–H hydrocarbons is achieved by a mechanistically des...

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Detalles Bibliográficos
Autores principales: Lee, Geun Seok, Park, Beomsoon, Hong, Soon Hyeok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440902/
https://www.ncbi.nlm.nih.gov/pubmed/36057676
http://dx.doi.org/10.1038/s41467-022-32851-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440902/
https://www.ncbi.nlm.nih.gov/pubmed/36057676
http://dx.doi.org/10.1038/s41467-022-32851-7

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