The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading
OBJECTIVES: Pancreatic reserve could be preserved by early assessment of pancreatic iron overload among transfusion-dependent sickle cell disease (SCD) patients. This study aimed to measure pancreatic iron load and correlate its value with patients’ laboratory and radiological markers of iron overlo...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440968/ https://www.ncbi.nlm.nih.gov/pubmed/36057708 http://dx.doi.org/10.1186/s13244-022-01280-x |
_version_ | 1784782473624813568 |
---|---|
author | Raief Mosaad, Basant Mohamed Ibrahim, Ahmed Samir Mansour, Mohamed G. ElAlfy, Mohsen Saleh Ebeid, Fatma Soliman Elsayed Abdeldayem, Emad H. |
author_facet | Raief Mosaad, Basant Mohamed Ibrahim, Ahmed Samir Mansour, Mohamed G. ElAlfy, Mohsen Saleh Ebeid, Fatma Soliman Elsayed Abdeldayem, Emad H. |
author_sort | Raief Mosaad, Basant Mohamed |
collection | PubMed |
description | OBJECTIVES: Pancreatic reserve could be preserved by early assessment of pancreatic iron overload among transfusion-dependent sickle cell disease (SCD) patients. This study aimed to measure pancreatic iron load and correlate its value with patients’ laboratory and radiological markers of iron overload. MATERIALS AND METHODS: Sixty-six SCD children and young adults underwent MRI T2* relaxometry using a simple mathematical spreadsheet and laboratory assessment. RESULTS: The results indicated moderate-to-severe hepatic iron overload among 65.2% of studied cases. None had cardiac iron overload. Normal-to-mild iron overload was present in the pancreas in 86% of cases, and 50% had elevated serum ferritin > 2500 ug/L. There was no significant correlation between pancreatic R2* level, serum ferritin, and hepatic iron overload. Patients with higher levels of hemolysis markers and lower pre-transfusion hemoglobin levels showed moderate-to-severe pancreatic iron overload. CONCLUSION: Chronically transfused patients with SCD have a high frequency of iron overload complications including pancreatic iron deposition, thereby necessitating proper monitoring of the body’s overall iron balance as well as detection of extrahepatic iron depositions. |
format | Online Article Text |
id | pubmed-9440968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-94409682022-09-05 The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading Raief Mosaad, Basant Mohamed Ibrahim, Ahmed Samir Mansour, Mohamed G. ElAlfy, Mohsen Saleh Ebeid, Fatma Soliman Elsayed Abdeldayem, Emad H. Insights Imaging Original Article OBJECTIVES: Pancreatic reserve could be preserved by early assessment of pancreatic iron overload among transfusion-dependent sickle cell disease (SCD) patients. This study aimed to measure pancreatic iron load and correlate its value with patients’ laboratory and radiological markers of iron overload. MATERIALS AND METHODS: Sixty-six SCD children and young adults underwent MRI T2* relaxometry using a simple mathematical spreadsheet and laboratory assessment. RESULTS: The results indicated moderate-to-severe hepatic iron overload among 65.2% of studied cases. None had cardiac iron overload. Normal-to-mild iron overload was present in the pancreas in 86% of cases, and 50% had elevated serum ferritin > 2500 ug/L. There was no significant correlation between pancreatic R2* level, serum ferritin, and hepatic iron overload. Patients with higher levels of hemolysis markers and lower pre-transfusion hemoglobin levels showed moderate-to-severe pancreatic iron overload. CONCLUSION: Chronically transfused patients with SCD have a high frequency of iron overload complications including pancreatic iron deposition, thereby necessitating proper monitoring of the body’s overall iron balance as well as detection of extrahepatic iron depositions. Springer Vienna 2022-09-04 /pmc/articles/PMC9440968/ /pubmed/36057708 http://dx.doi.org/10.1186/s13244-022-01280-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Raief Mosaad, Basant Mohamed Ibrahim, Ahmed Samir Mansour, Mohamed G. ElAlfy, Mohsen Saleh Ebeid, Fatma Soliman Elsayed Abdeldayem, Emad H. The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading |
title | The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading |
title_full | The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading |
title_fullStr | The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading |
title_full_unstemmed | The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading |
title_short | The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading |
title_sort | role of mri-r2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440968/ https://www.ncbi.nlm.nih.gov/pubmed/36057708 http://dx.doi.org/10.1186/s13244-022-01280-x |
work_keys_str_mv | AT raiefmosaadbasantmohamed theroleofmrir2inthedetectionofsubclinicalpancreaticironloadingamongtransfusiondependentsicklecelldiseasepatientsandcorrelationwithhepaticandcardiacironloading AT ibrahimahmedsamir theroleofmrir2inthedetectionofsubclinicalpancreaticironloadingamongtransfusiondependentsicklecelldiseasepatientsandcorrelationwithhepaticandcardiacironloading AT mansourmohamedg theroleofmrir2inthedetectionofsubclinicalpancreaticironloadingamongtransfusiondependentsicklecelldiseasepatientsandcorrelationwithhepaticandcardiacironloading AT elalfymohsensaleh theroleofmrir2inthedetectionofsubclinicalpancreaticironloadingamongtransfusiondependentsicklecelldiseasepatientsandcorrelationwithhepaticandcardiacironloading AT ebeidfatmasolimanelsayed theroleofmrir2inthedetectionofsubclinicalpancreaticironloadingamongtransfusiondependentsicklecelldiseasepatientsandcorrelationwithhepaticandcardiacironloading AT abdeldayememadh theroleofmrir2inthedetectionofsubclinicalpancreaticironloadingamongtransfusiondependentsicklecelldiseasepatientsandcorrelationwithhepaticandcardiacironloading AT raiefmosaadbasantmohamed roleofmrir2inthedetectionofsubclinicalpancreaticironloadingamongtransfusiondependentsicklecelldiseasepatientsandcorrelationwithhepaticandcardiacironloading AT ibrahimahmedsamir roleofmrir2inthedetectionofsubclinicalpancreaticironloadingamongtransfusiondependentsicklecelldiseasepatientsandcorrelationwithhepaticandcardiacironloading AT mansourmohamedg roleofmrir2inthedetectionofsubclinicalpancreaticironloadingamongtransfusiondependentsicklecelldiseasepatientsandcorrelationwithhepaticandcardiacironloading AT elalfymohsensaleh roleofmrir2inthedetectionofsubclinicalpancreaticironloadingamongtransfusiondependentsicklecelldiseasepatientsandcorrelationwithhepaticandcardiacironloading AT ebeidfatmasolimanelsayed roleofmrir2inthedetectionofsubclinicalpancreaticironloadingamongtransfusiondependentsicklecelldiseasepatientsandcorrelationwithhepaticandcardiacironloading AT abdeldayememadh roleofmrir2inthedetectionofsubclinicalpancreaticironloadingamongtransfusiondependentsicklecelldiseasepatientsandcorrelationwithhepaticandcardiacironloading |