The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading

OBJECTIVES: Pancreatic reserve could be preserved by early assessment of pancreatic iron overload among transfusion-dependent sickle cell disease (SCD) patients. This study aimed to measure pancreatic iron load and correlate its value with patients’ laboratory and radiological markers of iron overlo...

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Autores principales: Raief Mosaad, Basant Mohamed, Ibrahim, Ahmed Samir, Mansour, Mohamed G., ElAlfy, Mohsen Saleh, Ebeid, Fatma Soliman Elsayed, Abdeldayem, Emad H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440968/
https://www.ncbi.nlm.nih.gov/pubmed/36057708
http://dx.doi.org/10.1186/s13244-022-01280-x
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author Raief Mosaad, Basant Mohamed
Ibrahim, Ahmed Samir
Mansour, Mohamed G.
ElAlfy, Mohsen Saleh
Ebeid, Fatma Soliman Elsayed
Abdeldayem, Emad H.
author_facet Raief Mosaad, Basant Mohamed
Ibrahim, Ahmed Samir
Mansour, Mohamed G.
ElAlfy, Mohsen Saleh
Ebeid, Fatma Soliman Elsayed
Abdeldayem, Emad H.
author_sort Raief Mosaad, Basant Mohamed
collection PubMed
description OBJECTIVES: Pancreatic reserve could be preserved by early assessment of pancreatic iron overload among transfusion-dependent sickle cell disease (SCD) patients. This study aimed to measure pancreatic iron load and correlate its value with patients’ laboratory and radiological markers of iron overload. MATERIALS AND METHODS: Sixty-six SCD children and young adults underwent MRI T2* relaxometry using a simple mathematical spreadsheet and laboratory assessment. RESULTS: The results indicated moderate-to-severe hepatic iron overload among 65.2% of studied cases. None had cardiac iron overload. Normal-to-mild iron overload was present in the pancreas in 86% of cases, and 50% had elevated serum ferritin > 2500 ug/L. There was no significant correlation between pancreatic R2* level, serum ferritin, and hepatic iron overload. Patients with higher levels of hemolysis markers and lower pre-transfusion hemoglobin levels showed moderate-to-severe pancreatic iron overload. CONCLUSION: Chronically transfused patients with SCD have a high frequency of iron overload complications including pancreatic iron deposition, thereby necessitating proper monitoring of the body’s overall iron balance as well as detection of extrahepatic iron depositions.
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spelling pubmed-94409682022-09-05 The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading Raief Mosaad, Basant Mohamed Ibrahim, Ahmed Samir Mansour, Mohamed G. ElAlfy, Mohsen Saleh Ebeid, Fatma Soliman Elsayed Abdeldayem, Emad H. Insights Imaging Original Article OBJECTIVES: Pancreatic reserve could be preserved by early assessment of pancreatic iron overload among transfusion-dependent sickle cell disease (SCD) patients. This study aimed to measure pancreatic iron load and correlate its value with patients’ laboratory and radiological markers of iron overload. MATERIALS AND METHODS: Sixty-six SCD children and young adults underwent MRI T2* relaxometry using a simple mathematical spreadsheet and laboratory assessment. RESULTS: The results indicated moderate-to-severe hepatic iron overload among 65.2% of studied cases. None had cardiac iron overload. Normal-to-mild iron overload was present in the pancreas in 86% of cases, and 50% had elevated serum ferritin > 2500 ug/L. There was no significant correlation between pancreatic R2* level, serum ferritin, and hepatic iron overload. Patients with higher levels of hemolysis markers and lower pre-transfusion hemoglobin levels showed moderate-to-severe pancreatic iron overload. CONCLUSION: Chronically transfused patients with SCD have a high frequency of iron overload complications including pancreatic iron deposition, thereby necessitating proper monitoring of the body’s overall iron balance as well as detection of extrahepatic iron depositions. Springer Vienna 2022-09-04 /pmc/articles/PMC9440968/ /pubmed/36057708 http://dx.doi.org/10.1186/s13244-022-01280-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Raief Mosaad, Basant Mohamed
Ibrahim, Ahmed Samir
Mansour, Mohamed G.
ElAlfy, Mohsen Saleh
Ebeid, Fatma Soliman Elsayed
Abdeldayem, Emad H.
The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading
title The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading
title_full The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading
title_fullStr The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading
title_full_unstemmed The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading
title_short The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading
title_sort role of mri-r2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440968/
https://www.ncbi.nlm.nih.gov/pubmed/36057708
http://dx.doi.org/10.1186/s13244-022-01280-x
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