High prevalence of unusual KRAS, NRAS, and BRAF mutations in POLE ‐ hypermutated colorectal cancers

Exonucleasic domain POLE (edPOLE) mutations, which are responsible for a hypermutated tumor phenotype, occur in 1–2% of colorectal cancer (CRC) cases. These alterations represent an emerging biomarker for response to immune checkpoint blockade. This study aimed to assess the molecular characteristic...

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Detalles Bibliográficos
Autores principales: Favre, Loetitia, Cohen, Justine, Calderaro, Julien, Pécriaux, Adrien, Nguyen, Cong‐Trung, Bourgoin, Rémi, Larnaudie, Laura, Dupuy, Aurélie, Ollier, Marie, Lechapt, Emmanuèle, Sloma, Ivan, Tournigand, Christophe, Rousseau, Benoit, Pujals, Anaïs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441000/
https://www.ncbi.nlm.nih.gov/pubmed/35624529
http://dx.doi.org/10.1002/1878-0261.13257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441000/
https://www.ncbi.nlm.nih.gov/pubmed/35624529
http://dx.doi.org/10.1002/1878-0261.13257

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