Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK‐STAT signaling in macrophages by perturbing lipid raft structures

Survival of ovarian carcinoma is associated with the abundance of immunosuppressed CD163(high)CD206(high) tumor‐associated macrophages (TAMs) and high levels of arachidonic acid (AA) in the tumor microenvironment. Here, we show that both associations are functionally linked. Transcriptional profilin...

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Detalles Bibliográficos
Autores principales: Hammoud, Mohamad K., Dietze, Raimund, Pesek, Jelena, Finkernagel, Florian, Unger, Annika, Bieringer, Tim, Nist, Andrea, Stiewe, Thorsten, Bhagwat, Aditya M., Nockher, Wolfgang Andreas, Reinartz, Silke, Müller‐Brüsselbach, Sabine, Graumann, Johannes, Müller, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441005/
https://www.ncbi.nlm.nih.gov/pubmed/35451191
http://dx.doi.org/10.1002/1878-0261.13221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441005/
https://www.ncbi.nlm.nih.gov/pubmed/35451191
http://dx.doi.org/10.1002/1878-0261.13221

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