USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K

Oncogenic transformation of lung epithelial cells is a multistep process, frequently starting with the inactivation of tumour suppressors and subsequent development of activating mutations in proto‐oncogenes, such as members of the PI3K or MAPK families. Cells undergoing transformation have to adjus...

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Detalles Bibliográficos
Autores principales: Prieto‐Garcia, Cristian, Hartmann, Oliver, Reissland, Michaela, Braun, Fabian, Bozkurt, Süleyman, Pahor, Nikolett, Fuss, Carmina, Schirbel, Andreas, Schülein‐Völk, Christina, Buchberger, Alexander, Calzado Canale, Marco A., Rosenfeldt, Mathias, Dikic, Ivan, Münch, Christian, Diefenbacher, Markus E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441007/
https://www.ncbi.nlm.nih.gov/pubmed/35364627
http://dx.doi.org/10.1002/1878-0261.13217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441007/
https://www.ncbi.nlm.nih.gov/pubmed/35364627
http://dx.doi.org/10.1002/1878-0261.13217

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