Cardiac-specific Trim44 knockout in rat attenuates isoproterenol-induced cardiac remodeling via inhibition of AKT/mTOR pathway

When pathological hypertrophy progresses to heart failure (HF), the prognosis is often very poor. Therefore, it is crucial to find new and effective intervention targets. Here, myocardium-specific Trim44 knockout rats were generated using CRISPR-Cas9 technology. Cardiac phenotypic observations revea...

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Detalles Bibliográficos
Autores principales: Jiang, Xiao-yu, Guan, Fei-fei, Ma, Jia-xin, Dong, Wei, Qi, Xiao-long, Zhang, Xu, Chen, Wei, Gao, Shan, Gao, Xiang, Pan, Shuo, Wang, Ji-zheng, Ma, Yuan-wu, Zhang, Lian-feng, Lu, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441189/
https://www.ncbi.nlm.nih.gov/pubmed/35855640
http://dx.doi.org/10.1242/dmm.049444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441189/
https://www.ncbi.nlm.nih.gov/pubmed/35855640
http://dx.doi.org/10.1242/dmm.049444

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