Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicity

Costimulation of tumor-infiltrating T lymphocytes by anti-4-1BB monoclonal antibodies (mAbs) has shown anti-tumor activity in human trials, but can be associated with significant off-tumor toxicities involving FcγR interactions. Here, we introduce albumin-fused mouse and human bispecific antibodies...

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Detalles Bibliográficos
Autores principales: Hangiu, Oana, Compte, Marta, Dinesen, Anders, Navarro, Rocio, Tapia-Galisteo, Antonio, Mandrup, Ole A., Erce-Llamazares, Ainhoa, Lázaro-Gorines, Rodrigo, Nehme-Álvarez, Daniel, Domínguez-Alonso, Carmen, Harwood, Seandean L., Alfonso, Carlos, Blanco, Belen, Rubio-Pérez, Laura, Jiménez-Reinoso, Anaïs, Díez-Alonso, Laura, Blanco, Francisco J., Sanz, Laura, Howard, Kenneth A., Álvarez-Vallina, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441337/
https://www.ncbi.nlm.nih.gov/pubmed/36072551
http://dx.doi.org/10.1016/j.isci.2022.104958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441337/
https://www.ncbi.nlm.nih.gov/pubmed/36072551
http://dx.doi.org/10.1016/j.isci.2022.104958

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