Cytochrome P450-mediated antiseizure medication interactions influence apoptosis, modulate the brain BAX/Bcl-X(L) ratio and aggravate mitochondrial stressors in human pharmacoresistant epilepsy

Polytherapy with antiseizure medications (ASMs) is often used to control seizures in patients suffering from epilepsy, where about 30% of patients are pharmacoresistant. While drug combinations are intended to be beneficial, the consequence of CYP-dependent drug interactions on apoptotic protein lev...

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Detalles Bibliográficos
Autores principales: Ghosh, Chaitali, Westcott, Rosemary, Perucca, Emilio, Hossain, Mohammed, Bingaman, William, Najm, Imad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441576/
https://www.ncbi.nlm.nih.gov/pubmed/36515436
http://dx.doi.org/10.3389/fphar.2022.983233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441576/
https://www.ncbi.nlm.nih.gov/pubmed/36515436
http://dx.doi.org/10.3389/fphar.2022.983233

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