Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses

Plasmacytoid dendritic cells (pDCs) chronically produce type I interferon (IFN-I) in autoimmune diseases, including systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). We report that the IRE1α-XBP1 branch of the unfolded protein response (UPR) inhibits IFN-α production by TLR7- or TLR9-...

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Detalles Bibliográficos
Autores principales: Chaudhary, Vidyanath, Ah Kioon, Marie Dominique, Hwang, Sung-Min, Mishra, Bikash, Lakin, Kimberly, Kirou, Kyriakos A., Zhang-Sun, Jeffrey, Wiseman, R. Luke, Spiera, Robert F., Crow, Mary K., Gordon, Jessica K., Cubillos-Ruiz, Juan R., Barrat, Franck J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441715/
https://www.ncbi.nlm.nih.gov/pubmed/36053251
http://dx.doi.org/10.1084/jem.20221085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441715/
https://www.ncbi.nlm.nih.gov/pubmed/36053251
http://dx.doi.org/10.1084/jem.20221085

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