Cholinergic REST-G9a gene repression through HMGB1-TLR4 neuroimmune signaling regulates basal forebrain cholinergic neuron phenotype

Lipopolysaccharide (LPS) and high-mobility group box 1 (HMGB1) are Toll-like receptor (TLR4) agonists that activate proinflammatory neuroimmune signaling linked to loss of basal forebrain cholinergic neurons (BFCNs) and cognitive deficits. Loss of choline acetyltransferase immunoreactive (ChAT + IR)...

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Detalles Bibliográficos
Autores principales: Crews, Fulton T., Vetreno, Ryan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441808/
https://www.ncbi.nlm.nih.gov/pubmed/36072299
http://dx.doi.org/10.3389/fnmol.2022.992627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441808/
https://www.ncbi.nlm.nih.gov/pubmed/36072299
http://dx.doi.org/10.3389/fnmol.2022.992627

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